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The most important safety information and warning labels for tromethamine have been set forth in the box provided below.
CLINICAL PHARMACOLOGY
Mechanism of Action
Tromethamine (dimethenes) is a non-steroidal anti-inflammatory agent. In the human body, tromethamine binds to and activates the cysteine protease enzyme, causing a rapid, reversible, and irreversible reduction in the cysteine levels body. However, this decrease in cysteine content does not occur immediately. Cysteine metabolism is a complex biochemical process that is dependent on the presence of cysteine, a complex amino acids, and several cellular factors. The cysteine protease enzyme is also susceptible to degradation by a diverse array of biological processes, including heat and cold trauma, radiation, other environmental factors.
Tromethamine is metabolized by the cysteine protease enzyme. enzyme catalyzes the conversion of tromethamine to its active metabolite, cysteamine, a potent inhibitor of the human thrombogenesis cycle. At low doses of tromethamine, this inhibitory effect decreases the rate of blood clotting in tissue compartments containing large concentrations of thrombi, thereby decreasing the risk of bleeding.
In some situations, cysteamine may be converted to sulfinylcholine (and trimethoprim) by the sulfotransferase enzyme. However, enzyme does not catalyze the conversion of cysteamine to cysteine. Consequently, it remains for approximately 21 hours in the form of metabolites such as sulfhydrylcholine. The metabolite activity of sulfotransferase enzymes depends on the concentrations of cysteine in body at the time of interaction sulfotransferase enzymes with cysteine metabolites. At low doses, the activity of sulfotransferase enzymes is not strongly affected. For example, in healthy persons, the sulfotransferase enzyme activity of liver is approximately 30 fold higher than in the whole body, and sulfotransferase enzyme activity of the kidney is about 25-fold higher than in the whole body.
In healthy persons, the generic cymbalta available united states sulfotransferase enzymes that are active with the tromethamine metabolite occur predominantly in the tissue where tromethamine is found.
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Non-Steroidal Anti-Inflammatory Drugs:
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